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Responsilble AI

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  • Responsilble AI

Responsilble AI

Responsible Artificial Intelligence (AI) refers to the ethical and accountable design, development, deployment, and use of AI systems.

It prioritizes values such as transparency, fairness, accountability, and respect for human rights, ensuring that AI technologies are developed and applied in ways that promote well-being, equity, and social good, while minimizing potential harm [1].

According to the World Health Organization (WHO, 2021), achieving responsible AI in health requires alignment with six core ethical principles [2]

PRINCIPLES

1 Protecting human autonomy

Preserving human agency and clinical decision-making, especially in sensitive health interventions

2 Promoting human well-being, safety, and the public interest

Ensuring that AI technologies enhance patient outcomes and do not compromise safety

3 Ensuring transparency, explainability, and intelligibility

Making AI systems understandable, and their functions interpretable by end users and stakeholders

4 Fostering responsibility and accountability

Clearly delineating who is answerable for the performance and outcomes of AI systems

5 Ensuring inclusiveness and equity

Designing AI systems that address, rather than exacerbate, existing health inequities across populations

6 Promoting AI that is responsive and sustainable

Developing systems that are adaptable over time and environmentally responsible

These principles offer a robust ethical foundation to guide the development and use of AI in healthcare, enabling equitable, trustworthy, and effective innovation.

The WHO’s 2021 guidance also outlines ten key ethical challenges that must be proactively addressed to realize the potential of AI in health care responsibly [2]:

  1. Assessing whether AI should be used at all in certain clinical contexts.
  2. Addressing the digital divide to ensure equitable access to AI technologies.
  3. Ensuring ethical data collection, ownership, and usage practices.
  4. Establishing clear lines of accountability and responsibility in decision-making.
  5. Managing the implications of autonomous decision-making by AI systems.
  6. Identifying and mitigating bias and discrimination embedded in AI algorithms.
  7. Safeguarding against safety and cybersecurity risks posed by AI technologies.
  8. Preparing for labour market disruptions within the health sector.
  9. Navigating commercialization pressures that may conflict with public health interests.
  10. Evaluating the environmental impact of AI, particularly in the context of climate change.

These are not hypothetical concerns; they are pressing issues that demand robust governance frameworks, inclusive stakeholder engagement, and ethical foresight to ensure that AI advances in health care serve all populations—especially those in low-resource settings.

References

  1. Lyons JB, Hobbs K, Rogers S, Clouse SH. Responsible (use of) AI. Front Neuroergon. 2023 Nov 20;4:1201777. doi: 10.3389/fnrgo.2023.1201777. PMID: 38234494; PMCID: PMC10790885.
  2. World Health Organization. Ethics and governance of artificial intelligence for health: WHO guidance. Geneva: World Health Organization; 2021. https://www.who.int/publications/i/item/9789240029200

RESOURCES

+ Global frameworks

WHO (2021) Ethics and Governance of Artificial Intelligence for Health

WHO (2023) Regulatory considerations on artificial intelligence for health

WHO (2024) Ethics and governance of artificial intelligence for health: Guidance on large multi-modal models

OECD (2023) Advancing accountability in AI: Governing and managing risks throughout the lifecycle for trustworthy AI

OECD (2024) Collective Action for Responsible AI in Health

OECD (2024) AI in Health Huge Potential, Huge Risks

IMDRF (2022) Machine Learning-enabled Medical Devices: Key Terms and Definitions

IMDRF (2024) Medical Device Software Considerations

IMDRF (2025) Good machine learning practice for medical device development: Guiding principles

ITU (2022) FG-AI4H-DEL2.2 - Good practices for health applications of machine learning: Considerations for manufacturers and regulators

ITU (2022) DEL0.1 Common unified terms in artificial intelligence for health

ITU (2023) DEL7.4 Clinical evaluation of AI for health

UN (2024) Seizing the opportunities of safe, secure and trustworthy artificial intelligence systems for sustainable development : resolution / adopted by the General Assembly

UN (2023) Interim Report: Governing AI for Humanity

UNESCO (2022) UNESCO Recommendation on the Ethics of Artificial Intelligence

UNESCO (2023) Ethical Impact Assessment Tool 24

HealthAI (2024) Mapping AI Governance in Health From Global Regulatory Alignments to LMICs’ Policy Developments

 
+ Regional Regulations

G7 (2024) Hiroshima Process: Industry, Technology and Digital Minis terial Declaration and Annex3 “Advancing the Outcomes of the Hiroshima Artificial Intelligence Process (HAIP)”

   
+ Country specific

USA National Institute for Standards (NIST AI 100-1) (2024)

UK’s government Guidance Portfolio of AI assurance techniques (2023)

NICE Evidence standards framework for digital health technologies (2022)


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(("Artificial Intelligence"[Title/Abstract] OR "Machine Learning"[Title/Abstract] OR "Deep Learning"[Title/Abstract] OR "Natural Language Processing"[Title/Abstract]) AND ("Clinical care"[Title/Abstract] OR "clinical decision"[Title/Abstract] OR "Health"[Title/Abstract] OR "Healthcare"[Title/Abstract])) AND ("Health equit*"[Title/Abstract] OR "health disparit*"[Title/Abstract] OR "health inequalit*"[Title/Abstract] OR "ethic*"[Title/Abstract])


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